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M9490652.TXT
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1994-09-24
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Document 0652
DOCN M9490652
TI High serum prolactin levels in asymptomatic HIV-infected patients and in
patients with acquired immunodeficiency syndrome.
DT 9411
AU Graef AS; Gonzalez SS; Baca VR; Ramirez ML; Daza LB; Blanco FF; Ortiz
OA; Lavalle CM; Nuclear Medicine Department, Hospital de Especialidades,
Centro; Medico La Raza, Mexico City, Mexico.
SO Clin Immunol Immunopathol. 1994 Sep;72(3):390-3. Unique Identifier :
AIDSLINE MED/94340814
AB Prolactin (PRL) is an immunostimulatory hormone that is increased in
serum of patients with systemic lupus erythematosus (SLE). On the other
hand, SLE and AIDS patients share some clinical and immunologic
manifestations and probably share similar pathogenic factors and
etiology. Based on the above, we decided to investigate the serum PRL
levels in 22 asymptomatic HIV-infected patients, 32 patients with AIDS,
9 seronegative homosexual men, and 66 healthy controls. Antibodies to
HIV were determined by a micro-ELISA system and by HIV-1 Western blot.
Serum PRL was assayed by monoclonal antibodies. Serum PRL levels in the
control group were 5.07 +/- 1.36 ng/ml and in the seronegative
homosexual men were 5.81 +/- 1.45 ng/ml. Serum PRL levels in
asymptomatic HIV-infected patients were 9.22 +/- 3.3 ng/ml and in AIDS
patients were 10.26 +/- 2.5 ng/ml (P < 0.01 and P < 0.001, respectively,
for both groups when compared to healthy controls). The difference
between seronegative homosexual men and AIDS patients was P < 0.05. In
the present study we found that serum PRL levels in AIDS patients are
higher than in seronegative homosexual men and healthy controls; these
results are in agreement with a previous published report. Since PRL is
related to lymphocyte activation and lymphoproliferation, the finding
may have monitoring, prognostic, and therapeutic implications.
DE Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY Adolescence Adult
Human HIV Infections/*BLOOD/IMMUNOLOGY Male Middle Age
Prolactin/*BLOOD/PHYSIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).